MD Simulations of G1NC and G2NC G-beta and G-gamma and Prenylation Tail Interactions

Related to Figure 8 of manuscript:

Live-cell quantitative monitoring reveals distinct, high-affinity Gβγ regulations of GIRK2 and GIRK1/2 channels.

Reem Handklo1, Tal Keren Raifman1, Boris Shalomov1, Patrick Hofer3, Uri Kahanovitch1, Theres Friesacher3, Galit Tabak1, Vladimir Tsemakhovich1, Orna Chomsky-Hecht4, Debi Ranjan Tripathy1,4, Kerstin Zuhlke5, Carmen W. Dessauer6, Enno Klussmann5, Yoni Haitin1,2, Joel A. Hirsch2,4, Anna Stary-Weinzinger3, Daniel Yakubovich7, Nathan Dascal1,2

1 Department of Physiology and Pharmacology, School of Medicine, Tel Aviv University, Tel Aviv, Israel

2 Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, Israel

3 Department of Pharmaceutical Sciences, Division of Pharmacology and Toxicology, University of Vienna, Josef-Holaubek-Platz 2, 1090 Vienna, Austria.

4 Department of Biochemistry & Molecular Biology; Institute of Structural Biology,

George S. Weiss Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel

5 Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin, Germany

6 Department of Integrative Biology and Pharmacology, University of Texas Health Science

Center, Houston, Texas, USA

7 The Adelson School of Medicine, Ariel University, Ariel 4077625, Israel