DataSheet_1_Publication trends of research on sepsis and programmed cell death during 2002–2022: A 20-year bibliometric analysis.csv

BackgroundSepsis is considered an intractable dysfunction that results from the disordered host immune response to uncontrolled infection. Even though the precise mechanism of sepsis remains unclear, scientific advances have highlighted the key role of various programmed cell death processes in the pathophysiology of sepsis. The current study aims to explore the worldwide research trend on programmed cell death in the setting of sepsis and assesses the achievements of publications from various countries, institutions, journals, and authors globally.Material and methodsAssociated publications during 2002–2022 with the topical subject of sepsis and programmed cell death were extracted from the Web of Science. VOSviewer was utilized to evaluate and map the published trend in the relevant fields.ResultsAll 2,037 relevant manuscripts with a total citation of 71,575 times were screened out by the end of 1 January 2022. China accounted for the largest number of publications (45.07%) and was accompanied by corporate citations (11,037) and H-index (48), which ranked second globally. The United States has been ranked first place with the highest citations (30,775) and H-index (88), despite a low publication number (29.95%), which was subsequent to China. The journal Shock accounted for the largest number of publications in this area. R. S. Hotchkiss, affiliated with Washington University, was considered to have published the most papers in the relevant fields (57) and achieved the highest citation frequencies (9,523). The primary keywords on the topic of programmed cell death in sepsis remarkably focused on “inflammation” “immunosuppression”, and “oxidative stress”, which were recognized as the core mechanisms of sepsis, eventually attributing to programmed cell death. The involved research on programmed cell death induced by immune dysregulation of sepsis was undoubtedly the hotspot in the pertinent areas.ConclusionsThe United States has been academically outstanding in sepsis-related research. There appears to be an incompatible performance between publications and quantity with China. Frontier advances may be consulted in the journal Shock. The leading-edge research on the scope of programmed cell death in sepsis should preferably focus on immune dissonance-related studies in the future.

背景：败血症被视为一种难以治疗的机能障碍，它源于宿主对无法控制的感染所引发的免疫反应失调。尽管败血症的确切发病机制尚不明确，但科学进步已经凸显了各种程序性细胞死亡过程在败血症病理生理学中的关键作用。本研究旨在探讨败血症背景下程序性细胞死亡的全球研究趋势，并评估全球各国、机构、期刊和作者在相关领域的出版物成果。材料与方法：从2002年至2022年，通过Web of Science提取了与败血症和程序性细胞死亡相关的出版物。VOSviewer被用于评估和绘制相关领域的出版趋势。结果：截至2022年1月1日，共筛选出2,037篇相关论文，总引用次数为71,575次。中国发表的论文数量最多，占45.07%，其企业引用次数（11,037）和H指数（48）在全球排名第二。尽管美国发表论文数量较低（29.95%），但其引用次数（30,775）和H指数（88）位居全球第一。在这项研究中，期刊《休克》发表了最多的论文。华盛顿大学的R. S. Hotchkiss被认为是发表相关论文最多（57篇）且引用频率最高（9,523）的作者。关于败血症中程序性细胞死亡主题的关键词主要集中在“炎症”、“免疫抑制”和“氧化应激”上，这些被认为是败血症的核心机制，最终导致程序性细胞死亡。涉及败血症免疫失调诱导的程序性细胞死亡的研究无疑是相关领域的热点。结论：美国在败血症相关研究领域学术表现卓越。中国似乎在出版物数量与质量之间存在不匹配。前沿进展可在《休克》期刊中查阅。关于败血症中程序性细胞死亡的研究，未来应优先关注与免疫失调相关的研究领域。