Urinary uromodulin excretion contributed to renal function decline in the IgAN cohort (N = 185).

Analyses were performed using linear regression. Renal function decline was chosen as a dependent variable. Uromodulin was analyzed as a continuous variable in model I, and as a categorical variable in model II. In each analysis, physical and biochemical traits including age, gender, baseline-eGFR, baseline-MAP, baseline urinary protein, baseline urinary uromodulin, pathological changes (scored by Oxford system as M E S T ), time average MAP, time average urinary protein and type of treatment (with or without steroid/CTX) were first analyzed by single factor analysis. Baseline-eGFR, baseline urinary uromodulin, baseline urinary protein and TA-UP were associated with eGFR decline. Thus these four factors were included in the multiple factor analysis. The result from multiple factor analysis is presented. UUMOD: Urinary uromodulin; TA-UP: Time-average proteinuria.