Evaluation of functional disability after Chikungunya infection

Abstract INTRODUCTION: Chikungunya (CHIK) is caused by the Chikungunya virus, which is an Alphavirus of the Family Togaviridae transmitted to humans through female mosquitoes of the genus Aedes. METHODS: A cross-sectional study was conducted involving the administration of a questionnaire addressing sociodemographic and health variables and the Roland-Morris Disability Questionnaire on general pain to patients with CHIK in the City of Imperatriz, Brazil, between January and December 2017. RESULTS Data of a total of 130 patients were evaluated. The mean age was 52 years (standard deviation=13.3); majority of the patients were female (n=120) with a prevalence of 38.0% for functional disability. Statistical differences were noted for marital status (p=0.037), presence/absence of comorbidities (p=0.050), and the use of medications prior to the diagnosis of CHIK (p=0.050), use of methotrexate (p=0.030), use of nonsteroidal anti-inflammatory drugs (p≤0.035), and use of nonhormonal anti-inflammatory drugs (p=0.001). CONCLUSIONS Patients in the chronic phase of CHIK present functional disability, thus alerting healthcare professionals to the importance of implementing actions aimed at an adequate treatment in all phases of the disease, mainly related to pain treatment and motor rehabilitation.

【摘要 引言】基孔肯雅热（Chikungunya, CHIK）由基孔肯雅病毒（Chikungunya virus）引起，该病毒隶属于披膜病毒科（Togaviridae）甲病毒属（Alphavirus），可通过伊蚊属（Aedes）雌性蚊子叮咬传播至人类。

方法：本研究于2017年1月至12月在巴西因佩拉图斯市开展一项横断面研究，针对确诊基孔肯雅热的患者发放涵盖社会人口学与健康相关变量的调查问卷，并采用罗兰-莫里斯功能障碍问卷（Roland-Morris Disability Questionnaire）评估患者的一般性疼痛相关功能状态。

结果：本研究共纳入130例患者的临床数据进行分析，患者平均年龄为52岁（标准差=13.3）；其中绝大多数为女性（n=120），功能障碍患病率达38.0%。统计分析显示，婚姻状况（p=0.037）、合并症存在与否（p=0.050）、基孔肯雅热确诊前的用药情况（p=0.050）、甲氨蝶呤使用情况（p=0.030）、非甾体抗炎药（nonsteroidal anti-inflammatory drugs）使用情况（p≤0.035）以及非激素类抗炎药使用情况（p=0.001）均存在统计学差异。

结论：处于慢性期的基孔肯雅热患者存在功能障碍，这提示医护人员需重视在疾病全病程中实施恰当的治疗干预措施，尤其需聚焦疼痛管理与运动康复。