New Aminoimidazoles as BACE-1 Inhibitors: From Rational Design to Ab- lowering in Brain
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New Aminoimidazoles as BACE-1 Inhibitors: From Rational Design to Ab- lowering in Brain Descriptor: (2R)-2-cyclopropyl-5-methyl-2-[3-(5-prop-1-yn-1-ylpyridin-3-yl)phenyl]-2H-imidazol-4-amine, BETA-SECRETASE 1, DIMETHYL SULFOXIDE Authors: Rahm, F, Blid, J, Ginman, T, Karlstrom, S, Kihlstrom, J, Kolmodin, K, Lindstrom, J, von Berg, S, von Kieseritzky, F, Slivo, C, Swahn, B, Viklund, J, Olsson, L, Johansson, P, Eketjall, S, Falting, J, Jeppsson, F, Stromberg, K, Janson, J, Gravenfors, Y. Deposit date: 2012-07-10 Release date: 2012-10-10 Last modified: 2024-10-16 Method: X-RAY DIFFRACTION (1.95 Å) Cite: New aminoimidazoles as beta-secretase (BACE-1) inhibitors showing amyloid-beta (A beta ) lowering in brain. J. Med. Chem., 55, 2012
创建时间：
2012-07-10
