Significance of neutrophil to lymphocyte ratio and blood urea nitrogen to serum albumin ratio in patients with sepsis

Background: In emergency department (ED), management of severe sepsis leading to death is challenging. There is a need to find some early biomarkers, easily monitorable in ED that predict prognosis in sepsis. In this end, the goal of the study was to investigate the significance of neutrophil-to-lymphocyte ratio (NLR) combined with blood urea nitrogen to serum albumin ratio (BAR). Methods: The study cohort included a total of 337 patients with sepsis who were admitted to Lishui People's Hospital from June 2022 to June 2023. The cohort was divided into survival (255) and death (n=82) groups. We used the ROC curve for testing NLR, BAR and the combination of both, as prognosis markers of death. Results: When found that the NLR and BAR (P<0.05) were higher in the deceased patients than survivors. In addition, after adjusting for confounders, NLR (OR=1.052) and BAR (OR=1.095) were independent factors that influence prognosis in patients with sepsis (both P<0.05).The AUC for NLR combined with BAR was 0.798 (95% CI 0.745-0.850, P<0.05) and was higher than the single NLR (AUC = 0.776) and BAR (AUC = 0.701). Conclusion: NLR combined with BAR is highly relevant prognosis marker of patients with sepsis, which can be used in ED.