CBX4, UHRF2 SUMOylate ZNF131 with SUMO1

CBX4 (Pc2) and UHRF2 are able to SUMOylate ZNF131 on lysine-601 (lysine-567 in the isoform in Oh and Chung 2012, Oh and Chung 2013) . SUMOylation of ZNF131 increases the inhibition of ERalpha signaling by ZNF131 through suppression of ERalpha homodimerization.

CBX4（Pc2）与UHRF2能够对ZNF131的赖氨酸-601位（在Oh和Chung 2012、Oh和Chung 2013中的同源形式为赖氨酸-567）进行SUMO化修饰。ZNF131的SUMO化修饰通过抑制ERalpha同源二聚化，增强了ZNF131对ERalpha信号通路的抑制作用。