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Genome-wide profiling reveals cancer-related genes have switched alternative polyadenylation sites in colorectal cancer

ChEBI2018-02-02 更新2026-07-12 收录

结直肠癌基因组学

选择性多聚腺苷酸化

数据链接：

https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-MTAB-6403 数据链接链接失效反馈

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Genome-wide profiling reveals cancer-related genes have switched alternative polyadenylation sites in colorectal cancer

应用场景：

创建时间：

2018-02-02

RNA结合蛋白

选择性多聚腺苷酸化

The median correlation coefficients between RBPs and gULIs across experiments are indicated within the parenthesises.

NIAID Data Ecosystem100

Genome-wide enhancer-gene regulatory maps link causal variants to target genes underlying human colorectal cancer risk [ATAC-seq]. Genome-wide enhancer-gene regulatory maps link causal variants to target genes underlying human colorectal cancer risk [ATAC-seq]

结直肠癌基因组学

增强子-基因调控

Although GWASs have identified thousands of variants associated with human complex traits, most of which reside in the non-coding regions, especially enhancers, and biological mechanisms remain unclea

NIAID Data Ecosystem20

Multiple genes at the chromosome 20q amplicon contribute to colorectal adenoma to carcinoma progression

结直肠癌基因组学

染色体不稳定性

Chromosomal instability (CIN) is the hallmark of colorectal adenoma to carcinoma progression in 85% of cases, with 20q gain as the most prominent aberration. Yet, the oncogenes at this chromosomal gai

NIAID Data Ecosystem20

Alternative Polyadenylation Allows Differential Negative Feedback of Human miRNA miR-579 on Its Host Gene ZFR

内含子miRNA负反馈调控

选择性多聚腺苷酸化

About half of the known miRNA genes are located within protein-coding host genes, and are thus subject to co-transcription. Accumulating data indicate that this coupling may be an intrinsic mechanism

NIAID Data Ecosystem70

Intronic SNPs near splice sites (<30 nt).

基因组SNP分析

结直肠癌基因组学

aTissue samples with SNP detected by NGS. CRC is the colorectal cancer tissue, and CRN is the colorectal cancer adjacent normal tissue. b“+” indicates “validated” and “−” indicated “not tested” by Seq

NIAID Data Ecosystem20

Genome-wide profiling reveals cancer-related genes have switched alternative polyadenylation sites in colorectal cancer

资源简介：

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