Additional file 1 of Brain region–specific lipid alterations in the PLB4 hBACE1 knock-in mouse model of Alzheimer’s disease

Additional file 1: Supplementary Table S1. Summary of the lipid alterations in the PLB4 cortex, hippocampus, and hypothalamus. Lipid species listed show all the statistically significant alterations in the PLB4 brain compared to PLBWT. An unpaired, two-tailed Student’s T-test with Welch’s correction was performed using the average cpm data to determine statistically significant differences between PLBWT and PLB4 lipid species and brain regions: * p ≤ 0.05, ** p ≤ 0.01, *** p ≤ 0.001. A positive (+) percentage change denotes an increase in PLB4 compared to PLBWT, a negative (−) percentage change denotes a decrease in PLB4 compared to PLBWT. Abbreviations: cpm: counts per million, PE – phosphatidylethanolamine, PC – phosphatidylcholine, PI – phosphatidylinositol, TG – triacylglycerol, DG – diacylglycerol, PS – phosphatidylserine, Cer – ceramide, SM – sphingomyelin, PG – phosphatidylglycerol.