Transition-Metal-Free Carbofluorination of TBS-Protected Nitrogen-Containing Cyclic Enynols: Synthesis of Fluorinated Azabicycles
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The synthesis of fluorinated azabicycles from tert-butyldimethylsilyl-protected N-containing cyclic enynols using inexpensive BF3·OEt2 is described. In this reaction, BF3 reacts as both the Lewis acid and the fluoride source for cyclization/fluorination of the TBS-protected cyclic N-containing enynols. The method provides an easy access to fluorinated azabicycles where a new C(sp2)–F bond and a new bicyclic skeleton are generated at ambient temperature within 1–13 min under metal-free reaction conditions.
创建时间：
2016-02-19
