Original Images-Role and Mechanism of AOPPs-Induced NOX4-Mediated Ferroptosis in Intervertebral Disc Degeneration

NIAID Data Ecosystem2026-05-10 收录

椎间盘退变机制

铁死亡信号通路

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Original Images-Role and Mechanism of AOPPs-Induced NOX4-Mediated Ferroptosis in Intervertebral Disc Degeneration

创建时间：

2026-04-14

Reactive Oxygen Species promote Pyroptosis of Nucleus Pulposus Cells in Modic changes with disc herniation based on smart-RNA sequencing

椎间盘退变机制

焦亡与氧化应激

We performed Smart-seq 2 and analyzed the differential expression of genes and pathways of Modic change to comparator group. Additionally, we detect the role of reactive oxygen species on pyroptosis o

NIAID Data Ecosystem40

DataSheet1_Eupatilin attenuates the senescence of nucleus pulposus cells and mitigates intervertebral disc degeneration via inhibition of the MAPK/NF-κB signaling pathway.ZIP

椎间盘退变机制

NF-κB信号通路

Intervertebral disc degeneration (IDD) is the main cause of low back pain. An increasing number of studies have suggested that inflammatory response or the senescence of nucleus pulposus (NP) cells is

NIAID Data Ecosystem20

DataSheet7_Propofol Protects Myocardium From Ischemia/Reperfusion Injury by Inhibiting Ferroptosis Through the AKT/p53 Signaling Pathway.ZIP

心肌缺血再灌注损伤

铁死亡信号通路

The molecular mechanism underlying the protective role of propofol against myocardial ischemia/reperfusion (I/R) injury remains poorly understood. Previous studies have shown that ferroptosis is an im

NIAID Data Ecosystem10

Propionibacterium acnes induces intervertebral disc degeneration by promoting nucleus pulposus cell apoptosis via the TLR2/JNK/mitochondrial-mediated pathway

椎间盘退变机制

细胞凋亡通路

Evidence suggests that intervertebral disc degeneration (IVDD) can be induced by Propionibacterium acnes (P. acnes), although the underlying mechanisms are unclear. In this study, we analyzed the path

Figshare2019-04-02 更新20

Data_Sheet_2_Neuroprotective effect of Dl-3-n-butylphthalide against ischemia–reperfusion injury is mediated by ferroptosis regulation via the SLC7A11/GSH/GPX4 pathway and the attenuation of blood–brain barrier disruption.PDF

缺血性卒中神经保护

铁死亡信号通路

BackgroundStroke is one of the most severe diseases worldwide, resulting in physical and mental problems. Dl-3-n-butylphthalide, a compound derived from celery seed, has been approved for treating isc

NIAID Data Ecosystem10

Original Images-Role and Mechanism of AOPPs-Induced NOX4-Mediated Ferroptosis in Intervertebral Disc Degeneration

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