The incidence and severity of chronic UTI among inbred mouse strains.

APersistent Bacteriuria is defined as an individual mouse having greater than 104 cfu UTI89 KanR per ml of free catch urine at every time point through 4 weeks of infection. BResolved Bacteriuria is defined as an individual mouse having less than 104 cfu UTI89 KanR per ml of free catch urine at least once over 4 weeks of infection. CHere PPV is the positive predictive value of persistent bacteriuria in predicting the occurrence of bladder titers >104 cfu at 4 wpi, NPV is the negative predictive value of resolved bacteriuria in predicting the occurrence of bladder titers >104 cfu at 4 wpi. D5 mice were infected with wild type UTI89 in initial studies and these data are included in the analysis. E25 mice infected, 5 mice died by 7 dpi. F4 mice were infected with wild type UTI89 in initial studies and these data are included in the analysis. G6 C3H/HeSnJ mice were infected with 108 cfu wild type UTI89 in initial studies and these data are included in the analysis. *Incidence of persistent bacteriuria is significantly different from C3H/HeN mice (P<0.05, two-tailed Mann-Whitney). †Titers significantly different from those from mice that resolved bacteriuria (P<0.05, two-tailed Mann-Whitney). Limits of detection are Log10 transformed titers of 1.3-1.6 for bladders and 1.3 for kidneys.