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Essential Roles of the Smc5/6 complex in Replication through Pausing Sites and Endogenous DNA Damage Tolerance

Alliance of Genome Resources2026-08-01 收录

Smc5/6复合物功能

DNA损伤

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https://www.yeastgenome.org/dataset/GSE72241 数据链接链接失效反馈

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The essential functions of the conserved Smc5/6 complex remain elusive

进化保守的Smc5/6复合体（Smc5/6 complex）的核心功能仍难以阐明。

应用场景：

范可尼贫血机制

DNA损伤

Impaired DNA crosslink repair leads to Fanconi anemia (FA), characterized by a unique manifestation of bone marrow failure and pancytopenia among diseases caused by DNA damage response defects. As a r

Mendeley Data2024-01-31 更新160

Effect of DNA damage on ligand stimulated EGFR signaling pathways. Effect of DNA damage on ligand stimulated EGFR signaling pathways

EGFR信号通路

DNA损伤

We examined the cellular response of primary normal cells to EGFR stimulation under normal and DNA damage conditions. Overall design: Examining changes in the response to EGFR triggering in cells suff

NIAID Data Ecosystem80

Supplementary Material for: Catecholamine Metabolism Induces Mitochondrial DNA Deletions and Leads to Severe Adrenal Degeneration during Aging

腺体衰老机制

DNA损伤

Background: Aging is a multifactorial process characterized by organ loss of function and degeneration, but the mechanisms involved remain elusive. We have shown recently that catecholamine metabolism

NIAID Data Ecosystem30

Figure 2d Representative Photographs

细胞生物学

DNA损伤

The file shows representative images that went into Fig. 2d: Per2 induction limits lymphoid-biased haematopoietic stem cells and lymphopoiesis in the context of DNA damage and ageing. Wang J ,

DataCite Commons2020-08-27 更新90

Geant4-DNA simulations using complex DNA geometries generated by the DnaFabric tool

DNA损伤

DNA几何建模

This program has been imported from the CPC Program Library held at Queen's University Belfast (1969-2018) Abstract Several DNA representations are used to study radio-induced complex DNA damages de

NIAID Data Ecosystem50

Essential Roles of the Smc5/6 complex in Replication through Pausing Sites and Endogenous DNA Damage Tolerance

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