相关数据集
USP3,SAGA deubiquitinate Histone H2A,H2B
USP3 dynamically associates with chromatin and deubiquitinates H2A and H2B in vivo. The ZnF-UBP domain of USP3 mediates the H2A-USP3 interaction (Nicassio et al. 2007). USP22, a component of the hSAGA
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Simulating cell-free chromatin using preclinical cancer models for liquid biopsy applications
This SuperSeries is composed of the SubSeries listed below. Cell-free DNA circulates in blood bound to nucleosomes, forming cell-free chromatin (cfChromatin) that retains epigenetic features, includi
NIAID Data Ecosystem00
Metabolic reprogramming in astrocytes prevents neuronal death through a UCHL1/PFKFB3/H4K8la positive feedback loop
Astrocytic metabolic reprogramming is an adaptation of metabolic patterns to meet increased energy demands, although the role after spinal cord injury (SCI) remains unclear. Analysis of single-cell RN
NIAID Data Ecosystem00
Role of CxxC-finger Protein 1 in the Establishment of Epigenetic Landscapes in Mouse Oocytes. Role of CxxC-finger Protein 1 in the Establishment of Epigenetic Landscapes in Mouse Oocytes
During oogenesis, oocytes gain competence to accomplish meiotic maturation and prepare for embryonic development following fertilization. Trimethylated histone H3 on lysine-4 (H3K4me3) mediates a wide
NIAID Data Ecosystem40
Transcriptome-wide m6A methylome of endometrioid ovarian cancer and ovarian endometriosis
Emerging studies have revealed that N6-methyladenosine modification is involved in the development of various cancers. However, the m6A modification pattern of endometrioid ovarian cancer (EOC) has no
NIAID Data Ecosystem00
