Cryo-EM structure of ternary complex of human phosphoribosylglycinamidine synthase with the intermediate (iminophosphate) and ADP bound at the synthase site.

Cryo-EM structure of ternary complex of human phosphoribosylglycinamidine synthase with the intermediate (iminophosphate) and ADP bound at the synthase site. Descriptor: ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, N-[2-formamido-1-(phosphonooxy)ethylidene]-5-O-phosphono-beta-D-ribofuranosylamine, ... Authors: Sharma, N, French, J.B. Deposit date: 2025-02-12 Release date: 2026-02-25 Last modified: 2026-04-08 Method: ELECTRON MICROSCOPY (3.22 Å) Cite: Structural and molecular basis for allosteric regulation and catalytic coupling of human phosphoribosylformylglycinamidine synthase. Nat Commun, 17, 2026