TumorHoPe2: An updated database for Tumor Homing Peptides

TumorHoPe2: An updated database for Tumor Homing Peptides Welcome to the official repository and documentation overview for TumorHoPe2, an extensively updated and enhanced version of the original TumorHoPe database. This resource serves as a comprehensive platform for the study of Tumor Homing Peptides (THPs)—short amino acid sequences that specifically recognize and bind to tumor cells or their vascular microenvironment. Web Server: https://webs.iiitd.edu.in/raghava/tumorhope2/ Git Hub Link: https://github.com/sudhanshus-hash/TumorHoPe2 Citation Kashyap, D., Gupta, D., Mehta, N. K., & Raghava, G. P. S. (2025). TumorHoPe2: An updated database for Tumor Homing Peptides. Preprint/Manuscript. https://doi.org/10.48550/arXiv.2505.20913 About the Database TumorHoPe2 was developed to provide a significantly expanded and more detailed resource compared to its predecessor. It catalogs experimentally validated peptides that home into tumor tissues through the circulatory system, facilitating the development of targeted cancer therapeutics, diagnostics, and theranostics. The updated database integrates data from: Expanded Literature Search: Exhaustive curation of studies published between 2011 and 2024. Validated Experiments: Data from in vivo (e.g., phage display, biodistribution) and in vitro (e.g., cell binding, internalization) assays. Diverse Biological Sources: Peptides targeting various tumor types, cell lines, and specific receptors.