C−H and C−S Activations of Quinoline-Functionalized Thiophenes by Platinum Complexes

We synthesized and characterized two ligands, 2-(quinolin-8-yl)thiophene (1a) and 3-(quinolin-8-yl)thiophene (1b). The selective C−H activation of the thiophene moieties was achieved by reacting 1a or 1b and [Pt(CH3)2(SMe2)]2. We observed η2-thiophene intermediates during the course of the reactions. The selective C−S bond activation of the thiophene moieties was observed after reacting 1a or 1b and [Pt(dippe)H]2. DFT calculations were performed to elucidate the regioselectivity of C−S activations.