Divergent Approach to Thiazolylidene Derivatives: A Perspective on the Synthesis of a Heterocyclic Skeleton from β‑Amidothioamides Reactivity

Herein we report a domino protocol
able to reach regioselectively
thiazolylidene systems by combining the reactive peculiarities of
both β-amidothioamides (ATAs) and 1,2-diaza-1,3-dienes (DDs).
Depending on the reaction conditions and/or the nature of the residue
at C4 of the heterodiene system, ATAs can act as hetero-mononucleophiles
or hetero-dinucleophiles in the diversified thiazolylidene ring assembly.