CIViC Assertion

A CIViC assertion classifies the clinical significance of a variant-disease relationship under recognized guidelines. The CIViC Assertion (AID) summarizes a collection of Evidence Items (EIDs) that covers predictive/therapeutic, diagnostic, prognostic or predisposing clinical information for a variant in a specific cancer context. CIViC currently has two main types of Assertions: those based on variants of primarily somatic origin (predictive/therapeutic, prognostic, and diagnostic) and those based on variants of primarily germline origin (predisposing). When the number and quality of Predictive, Prognostic, Diagnostic or Predisposing Evidence Items (EIDs) in CIViC sufficiently cover what is known for a particular variant and cancer type, then a corresponding assertion be created in CIViC.

CIViC 断言对在公认指南下变异-疾病关系的临床意义进行分类。CIViC 断言（AID）概述了一组证据项目（EIDs），这些项目涵盖了针对特定癌症背景中变异的预测/治疗、诊断、预后或易感性的临床信息。目前，CIViC 拥有两种主要的断言类型：基于主要起源于体细胞的变异（预测/治疗、预后和诊断）的断言，以及基于主要起源于生殖细胞的变异（易感性）的断言。当 CIViC 中的预测、预后、诊断或易感性证据项目（EIDs）的数量和质量充分覆盖了特定变异和癌症类型已知信息时，则应在 CIViC 中创建相应的断言。