SARS-CoV-2 Variant Delta Potently Suppresses Innate Immune Response and Evades Interferon-Activated Antiviral Responses in Human Colon Epithelial Cells

Here we report differential regulation of innate immune response by SARS-CoV-2 variants and immune antagonism by Alpha and Delta variant. Overall design: Caco-2 cells were infected with four different variant isolates of SARS-CoV-2 for 24-, 48- and 72 hrs and the differential host gene expression was performed by RNA deep sequencing.