The objective is to investigate the efficacy and safety of raltitrexed combined with Irinotecan (SALIRI) based regimen as first-line treatment for advanced metastatic colorectal cancer(mCRC).
Interventions: experimental group:Apatinib combined with oxaliplatin and capecitabine (XELOX) g Primary outcome(s): Disease free survival Study Design: Single arm
Note: DMA-25, DMA-50, and DMA-100 represent DMAMCL at doses of 25, 50, and 100 mg/kg, respectively. Inhibition represents the percent decrease in tumor weight compared to the vehicle group. *p < 0.05,
5-Fluorouracil-nicotinamide (5-FU-NCM), a co-crystal with a 2D layer structure formed by hydrogen bonds, was synthesized by solvent evaporation and liquid phase-assisted grinding at room temperature.
