Pharmacogenomics Study of CPT-11 as the First-line Chemotherapy for mCRC
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https://www.omicsdi.org/dataset/ecrin-mdr-crc/2101269
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资源简介：
Irinotecan (CPT-11) is now widely used as the first-line chemotherapy for mCRC. There were 4 key enzymes for CPT-11 metabolizing, CYP3A4, UDP-glucuronosyltransferase, carboxylesterase(CES), and ATP-binding cassette (ABC) transporters. Genetic variations of those enzymes may cause the heterogeneity in safety and efficacy of CPT-11. The aim of this study is to figure out the correlation between the genetic polymorphism and the drug response.
创建时间：
2010-11-15
