Cocaine-related DNA methylation in neurons in the caudate nucleus alters the three dimensional structure of the IRXA gene cluster

This study investigates differences in DNA methylation that are associated with chronic cociane dependence in post-mortem dorsolateral caudate tissue samples from human brain. The data were generated with reduced representation bisulfite sequencing (RRBS) and compared to data generated in caudate tissue from psychiatrically healthy controls. This study generated RRBS libraries from 28 males with a history of chronic cocaine dependence and cocaine toxicology at time of death, and 29 drug-naïve males. Each sample was sequenced at least twice and raw reads were pooled for each individual. Raw data files represent pooled sequencing reads for each individual.