We sorted GFP-labeled 4T1 cells from primary tumors and lung metastases and performed methylation-seq. Compare DNA methylation levels between primary tumors and lung metastases in 4T1 mouse mammary tu
The ability to induce pluripotent stem cells from committed, somatic human cells provides tremendous potential for regenerative medicine. However, there is a defined neoplastic potential inherent to s
Several homeobox-related gene (HOX) transcription factors such as mesenchyme HOX-2 (MEOX2) have previously been associated with cancer drug resistance, malignant progression and/or clinical prognostic
Our study demonstrates that combined treatment with the EZH2 inhibitor tazemetostat and the KRAS inhibitor RMC-6236 markedly activates the expression of senescence-associated secretory phenotype (SASP
