Human protein-protein interaction network database search

This repository is no longer available. A human interactome map. The sequencing of the human genome has provided a surprisingly small number of genes, indicating that the complex organization of life is not reflected in the gene number but, rather, in the gene products – that is, in the proteins. These macromolecules regulate the vast majority of cellular processes by their ability to communicate with each other and to assemble into larger functional units. Therefore, the systematic analysis of protein-protein interactions is fundamental for the understanding of protein function, cellular processes and, ultimately, the complexity of life. Moreover, interactome maps are particularly needed to link new proteins to disease pathways and the identification of novel drug targets.

本存储库已不再可用。此项目为一幅人类相互作用组图谱。人类基因组测序结果出人意料地显示了极少的基因数量，这表明生命的复杂组织并非体现在基因数量上，而是在于基因产物——即蛋白质。这些生物大分子通过其相互通讯的能力以及组装成更大功能单元的能力，调节着绝大多数细胞过程。因此，对蛋白质-蛋白质相互作用的系统性分析对于理解蛋白质功能、细胞过程，乃至生命的复杂性至关重要。此外，相互作用组图谱对于将新蛋白质与疾病通路相联系以及识别新型药物靶点尤为重要。