RAF activation

This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>

本事件系通过计算推理得出，其基于对其他物种中已证实事件的演绎。推理过程依托于PANTHER的同源映射。概括而言，对于所有涉及物理实体（包括输入、输出及催化剂）均存在映射同源/旁系同源（对于复合体而言，至少75%的组分必须具有映射）的反应，均被演绎至其他物种。同时，为便于导航，对这些事件也进行了高级别事件的推断。<p>关于Reactome中事件推理的更多细节及注意事项，请参阅：<a href='/electronic_inference_compara.html' target = 'NEW'>事件推理的详细信息及注意事项。</a>有关PANTHER的详细信息，请参阅：<a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>