Unlocking the Potential of High-Throughput Experimentation for Electrochemistry with a Standardized Microscale Reactor

Organic electrochemistry has emerged
as an enabling and sustainable
technology in modern organic synthesis. Despite the recent renaissance
of electrosynthesis, the broad adoption of electrochemistry in the
synthetic community, and especially in industrial settings, has been
hindered by the lack of general, standardized platforms for high-throughput
experimentation (HTE). Herein, we disclose the design of the HTe–Chem, a high-throughput
microscale electrochemical reactor that is compatible with existing
HTE infrastructure and enables the rapid evaluation of a broad array
of electrochemical reaction parameters. Utilizing the HTe–Chem to accelerate reaction optimization,
reaction discovery, and chemical library synthesis is illustrated
using a suite of oxidative and reductive transformations under constant
current, constant voltage, and electrophotochemical conditions.