Development of a Genetic Priority Score to Predict Drug Side Effects Using Human Genetic Evidence

This Zenodo repository contains the data associated with the publication: Duffy, Á et al. Development of a Genetic Priority Score to Predict Drug Side Effects Using Human Genetic Evidence. Submitted You can explore these scores further at https://rstudio-connect.hpc.mssm.edu/sideeffect-geneticpriorityscore/. Repository contents This archive contains all data necessary to reproduce the analyses described in the manuscript. The corresponding analysis scripts can be cloned from https://github.com/rondolab/SE-GPS. Files within Data.zip include: Processed drug–genetic datasets at the drug-gene-parentterm level: Opentargets_dataset_se.mi_withgeneticsfiltered_5_All_parentterm_drugse_final.txt.gz Onsides_dataset_se.mi_withgeneticsfiltered_5_All_parentterm_drugse_final.txt.gz Severe drug side effect subset: Withdrawndrugs_dataset_Opentargets_outcome_senomi_phase4.txt Opentargets_dataset_drugwarnings_filtered_5_All_drugse_final.txt Withdrawndrugs_dataset_Onsides_outcome_senomi_phase4.txt Onsides_dataset_drugwarnings_filtered_5_All_drugse_final.txt Severity scoring files: Adr_severity_scores_phecodeX.txt PhecodeX information: phecodeX_info.csv All gene dataset for 19,422 protein-coding genes and 502 phecodes Allgenes_dataset_parentterm_predictors_collapsed_sideeffect_project.txt.gz Allgenes_dataset_phenotype_predictors_stringentfilters_sideeffect_project.txt.gz LOF and GOF evidence for each feature: Predictors_with_direction_effect_sideeffect_project_gof_predvalue.txt Predictors_with_direction_effect_sideeffect_project_lof_predvalue.txt Processed drug–genetic datasets with directional evidence Opentargetsgeneticdataset_filtered_5_All_DOE_matchmechanism.txt.gz Onsidesgeneticdataset_filtered_5_All_DOE_matchmechanism.txt.gz Note, we use the word parentterm to refer to the phecodeX integer.