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Sequential Rearrangement of 1,2,4<i>Z</i>,7-Tetraenes Involving [1,5]-Hydrogen Migration and Electrocyclization: An Efficient Synthesis of Eight-Membered Cyclic Compounds

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NIAID Data Ecosystem2026-03-06 收录
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An efficient protocol for the synthesis of eight-membered bicyclic compounds from the cycloisomerization of 1,2,4Z,7-tetraenes has been established. The possible intermediate for this transformation was trapped by its Diels−Alder reaction with N-ethyl maleimide. Thus the reaction may proceed via the sequential processes involving [1,5]-hydrogen migration and electrocyclization.

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2016-05-05
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