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We developed an enhanced fusion variant, makes it an effective CRISPRa tool
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创建时间：
2024-02-06
相关数据集
BET inhibitors enhance the expression of fetal and embryonic hemoglobin genes [K562]
We performed RNA-sequencing on erythroid cell lines treated with DMSO or JQ1. We found that JQ1 induces erythropoiesis and specifically upregulated fetal and embryonic globin genes at the beta globin
NIAID Data Ecosystem60
Single-nucleotide–level mapping of DNA regulatory elements that control fetal hemoglobin expression
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
NIAID Data Ecosystem40
Micro-Capture-C to determine the long-range interaction of HBG1/2 promoter with the locus control region (LCR), a powerful upstream enhancer in -175 A>G mutantant HUDEP-2 cells.. Micro-Capture-C to determine the long-range interaction of HBG1/2 promoter with the locus control region (LCR), a powerful upstream enhancer in -175 A>G mutantant HUDEP-2 cells.
Naturally occurring mutations in the γ-globin promoters can result in hereditary persistence of fetal hemoglobin (HPFH), a benign condition that ameliorates the severity of β-hemoglobinopathies throug
NIAID Data Ecosystem00
NFI factors repress fetal hemoglobin in adult erythorid cells [ATAC-seq]
The mechanisms by which the fetal type b-globin-like genes HBG1 and HBG2 are silenced in adult erythroid precursor cells is a basic biology question in human development. Reversal of such mechanisms i
NIAID Data Ecosystem60
Temporal resolution of gene derepression and proteome changes upon PROTAC-mediated degradation of BCL11A protein in erythroid cells [Bisulfite-seq]
We acutely depleted the BCL11A protein by using the dTAG PROTAC technology, and assessed its immediate consequences on DNA methylation at the HBG1/2 promoter region. Overall design: Examination of cha
NIAID Data Ecosystem20
