Expression profiling in liver of wild type and Ppara-null mice treated with PPARA agonists [RNA-seq]

To clarify the mechanism underlying the proliferation of hepatocytes induced by PPARA agonists, expression profiling in liver of wild type and Ppara-null mice treated with PPARA agonist was investigated. Overall design: RNA was extracted from the liver of wild type (Ppara+/+), and Ppara-null (Ppara-/-) mice treated with the PPARA agonist (Wy14,643 or Fenofibrte). RNA purified were then used to generate libraries and sequenced.