WP3876 - BMP2-WNT4-FOXO1 pathway in primary endometrial stromal cell differentiation - Homo sapiens
收藏NIAID Data Ecosystem2026-05-02 收录
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https://www.ndexbio.org/viewer/networks/b3bd6543-5c6c-11ec-b3be-0ac135e8bacf
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资源简介：
This pathway is based on figure 6 from Li et al. BMP2 is activated by cAMP which promotes WNT4 expression in Human Primary Endometrial Stromal Cells (HPESCs) through SMAD1/5/8. WNT4 then induces FOXO1 function through B-Catenin which indirectly stimulates HPESC differentiation. DKKs and SFRPs are activated by BMP2 inhibit WNT4 and stop downstream signaling.
Proteins on this pathway have targeted assays available via the [CPTAC Assay Portal](https://assays.cancer.gov/available_assays?wp_id=WP3876)
创建时间：
2025-04-17
