Propionyl-CoA catabolism

Propionyl-CoA is a product of the catabolism of the amino acids, leucine, methionine, and threonine, and of the beta-oxidation of fatty acids with odd numbers of carbon atoms. The three reactions of this pathway convert propionyl-CoA to succinyl-CoA, an intermediate of the citric acid cycle. Through these reactions, carbon atoms from these sources can be fully oxidized to produce energy, or can be directed to gluconeogenesis. The three reactions of propionyl-CoA catabolism take place in the mitochondrial matrix.

丙酰辅酶A为氨基酸异亮氨酸、蛋氨酸和苏氨酸的分解代谢产物，以及奇数碳原子的脂肪酸β-氧化的产物。该途径中的三个反应将丙酰辅酶A转化为琥珀酰辅酶A，这是三羧酸循环的中间产物。通过这些反应，来自这些来源的碳原子可以被完全氧化以产生能量，或者可以被引导至糖异生。丙酰辅酶A的分解代谢反应发生在线粒体基质中。