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Highly Enantioselective Monofluoromethylation of C2-Arylindoles Using FBSM under Chiral Phase-Transfer Catalysis

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NIAID Data Ecosystem2026-03-07 收录
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https://figshare.com/articles/dataset/Highly_Enantioselective_Monofluoromethylation_of_C2_Arylindoles_Using_FBSM_under_Chiral_Phase_Transfer_Catalysis/2398645
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The highly enantioselective addition of 1-fluoro-1,1-bis(phenylsulfonyl)methane (FBSM) to vinylogous imines generated in situ from 2-aryl-3-(1-arylsulfonylmethyl)indoles was achieved using chiral ammonium salts derived from cinchona alkaloids. One-pot conversion from 2-arylindoles with FBSM was also adaptable under the same reaction conditions. The key for this transformation is the effective use of the arylsulfonyl group.
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2016-02-19
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