Chrna5 overexpresses in Psoriasis patients and Promotes Psoriasis-Like Inflammation in mice model

It is well known that psoriasis is closely related to smoking, while cholinergic receptor nicotinic alpha 5 subunit plays an important role in smoking-related diseases. However, studies on the relationship between Chrna5 and psoriasis are limited. This study aims to explore the role of Chrna5 in the development and possible pathogenesis of psoriasis. Analysis from psoriasis tissues and imiquimod mouse modle showed that Chrna5 was highly expressed in psoriasis skin lesions. In order to further verify the function of Chrna5, we constructed Chrna5 knockout mice and re-performed psoriasis modeling.