Supplementary Materials for manuscript “Comparative genomics of three non-hematophagous leeches (Whitmania spp.): focusing on antithrombotic genes”

Leeches are well known for their blood-feeding habits and are widely used for medicinal purposes as they secrete various antithrombotic substances. However, some leeches such as Whitmania spp. exhibit non-hematophagous feeding habits and their significance for medicinal use is debated. Here, we provide two nearly complete high quality genomes of Whitmania acranulata and Whitmania laevis. We also identified many antithrombic gene families involved in anticoagulation, anti-platelet aggregation, fibrinolysis, and drug diffusion. Our results will greatly facilitate the evolutionary research and application of leech derivatives for medical and pharmaceutical purposes of thrombosis.File_S1_Wacr.genome.zip: Supplementary File S1, the genome assembly of W. acranulata.File_S2_Wlae.genome.zip: Supplementary File S2, the genome assembly of W. laevis.File_S3_Wacr.gff.zip: Supplementary File S3, the GFF file of W. acranulata.File_S4_Wlae.gff.zip: Supplementary File S4, the GFF file of W. laevis.File_S5_Wacr.anti.fas: Supplementary File S5, coding sequences of all antithrombotic genes of W. acranulata.File_S6_Wlae.anti.fas: Supplementary File S6, coding sequences of all antithrombotic genes of W. laevis.