Sixty-minute inhalation of molecular hydrogen decreases blood oxygen saturation but does not alter autonomic cardiac regulation at rest in healthy females: A randomized, double-blind, placebo-controlled crossover study

This randomized, double-blind, placebo-controlled crossover study investigated the effects of 60-minute molecular hydrogen inhalation on oxygen saturation and heart rate variability in healthy females. Twenty physically active participants completed two inhalation sessions with either molecular hydrogen or placebo (ambient air), separated by a seven-day washout period. Oxygen saturation and heart rate variability were monitored during 60 minutes of inhalation. The dataset contains basic anthropological characteristics of participants. The oxygen saturation value represents the average value taken from a 5-minute segment. The heart rate variability values represent the time- and frequency-domain indices calculated from a 5-minute segment., Experimental protocol
The research was conducted as a randomized, double-blind, placebo-controlled crossover study. Twenty physically active female sports science students years were divided randomly into two experimental groups. One group inhaled molecular hydrogen and the other group inhaled a placebo for 60 minutes. Following a seven-day washout period, a second experimental session was conducted where molecular hydrogen and placebo inhalation were reversed. Molecular hydrogen (flow of 300 ml/min, purity of 99.8%) was produced by a generator i300 (Molecular Hydrogen Medical Technologies, Ostrava, Czech Republic). Placebo was delivered using a modified generator that pumps ambient air. Participants were seated and a chest strap (Polar Pro Strap, Polar, Kempele, Finland) was placed. A pulse oximeter sensor was placed on right index finger. They were then fitted with a nasal cannula supplying molecular hydrogen or placebo. Subsequently, SpO2 and ECG signal were recorded for 60 minutes i..., # Sixty-minute inhalation of molecular hydrogen decreases blood oxygen saturation but does not alter autonomic cardiac regulation at rest in healthy females: A randomized, double-blind, placebo-controlled crossover study

Dataset DOI: [10.5061/dryad.9ghx3ffwv](https://doi.org/10.5061/dryad.9ghx3ffwv)

## Description of the data and file structure

The dataset is stored in a single Excel file with two lists. The list titled “Participants” contains the anthropological characteristics of the participants. The list titled “Experiment” contains values from two experimental sessions.

### Files and variables

### File: raw_data.xlsx

#### List \"Participants\"

##### Variables

* \"Participant\": anonymized label for each participant.
* \"Inhalation\": type of inhalation in the first session. H2 means molecular hydrogen, Pla means placebo. The inhalation is reversed in the second session.
* \"Body mass\": body mass in kg.
* \"Body fat\": body fat percentage determined by bioimpedance analysis.

###..., All participants signed informed consent in which they agreed to the public sharing of de-identified data. Values that could identify a participant were removed from the dataset.