The data of study about the chitosan-selenium nanoparticles on depression-like behaviour induced by fluoride in mice via JAK2-STAT3 pathway

Data 18 firstly showed an unprecedented and very important finding was that 150 mg/L Sodium fluoride (NaF) resulted in the insufficient Se content in cortex. However, CS-SeNPs supplementation was beneficial to cortical Se retention in a dose-dependent manner and could antagonize fluoride-induced cortical Se depletion in data 18, which implied that oral administration of CS-SeNPs could be an effective way to supply Se. Further data 20 and 21 suggested that NaF decreased DA and NE content in the cortex, and 1 mg/kg·bw CS-SeNPs reduced the content of DA and NE, and 2 mg/kg·bw CS-SeNPs reduced the DA levels, while 0.5 mg/kg·bw CS-SeNPs had no obvious impact on the content of DA and NE, suggesting that long-term intake of 1, and 2 mg/kg·bw CS-SeNPs had potential negative effects on the monoamine nervous system. Interestingly, data 20 and 21 demonstrated that 0.5 and 1 mg/kg·bw CS-SeNPs protected against dopaminergic and noradrenergic damage caused by NaF in the cortex of mice in this research, which provided the theoretical basis for CS-SeNPs to exert antidepressant - like behavior. Raw data 22-24 showed that the decreased CORT secretion was induced by fluoride in the cortex, however, the expression of GR was significantly increased in the cortex exposed to fluoride, and there was no obvious change of CRF. 0.5 mg/kg·bw and 2 mg/kg·bw CS-SeNPs significantly increased the secretion of CORT and CRF, and 0.5 mg/kg·bw CS-SeNPs significantly decreased the expression of GR, suggesting that CS-SeNPs may improve the response of HPA axis to stress. What’s more, CS-SeNPs of 0.5 mg/kg·bw, 1 mg/kg·bw and 2 mg/kg·bw reestablished the fluoride-reduced CORT secretion. These results demonstrated that the mechanisms of fluoride-induced depression-like behavior were mainly related to the abnormal secretion of monoamine neurotransmitters, rather than the abnormal hyperactivity of the HPA axis. And 0.5 mg/kg·bw and 1 mg/kg·bw CS-SeNPs reversed the abnormal secretion of monoamine neurotransmitters. These data can be used for reference or comparison to further understand the neurotoxicity of long-term use of CS-SeNPs. At the same time, these data provide a comparison of the neurotoxicity of different doses of CS-SeNPs. 0.5 mg/kg·bw provides a relatively safe threshold for long-term consumption CS-SeNPs.