Crystal structure of PRMT5:MEP50 in complex with MTA and oxamide compound 23
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Crystal structure of PRMT5:MEP50 in complex with MTA and oxamide compound 23 Descriptor: 1,2-ETHANEDIOL, 5'-DEOXY-5'-METHYLTHIOADENOSINE, Methylosome protein 50, ... Authors: Whittington, D.A. Deposit date: 2023-12-20 Release date: 2024-04-24 Last modified: 2024-11-13 Method: X-RAY DIFFRACTION (2.46 Å) Cite: Discovery of TNG908: A Selective, Brain Penetrant, MTA-Cooperative PRMT5 Inhibitor That Is Synthetically Lethal with MTAP -Deleted Cancers. J.Med.Chem., 67, 2024
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2023-12-20
