An Approach to 3‑(Indol-2-yl)succinimide Derivatives by Manganese-Catalyzed C–H Activation

The manganese-catalyzed
addition of C-2 position of indoles to
maleimides has been achieved under additive-free conditions. The manganese
catalyst exhibits excellent chemo- and regioselectivity, good functional
group compatibility, and high catalytic efficiency. The substrate
scope can also be extended to maleates, ethyl acrylate, 1,4-dihydro-1,4-epoxynaphthalene,
pyrroles, and 2-phenylpyridine, which further demonstrates the universality
of this straightforward approach.