Supplementary Material for: Predictor Variables of Developing Anterior Pituitary Deficiencies in a Group of Paediatric Patients with Central Diabetes Insipidus and Langerhans Cell Histiocytosis

Background: Langerhans cell histiocytosis (LCH) is a
rare histiocytic disorder of unknown etiopathogenesis. Central diabetes
insipidus (CDI) is the most frequent endocrine manifestation and is a
known risk factor for the development of further anterior pituitary
hormone deficiencies (APD). However, not all CDI patients develop APD,
as observed during prolonged periods of follow-up. Aim: To find predictors of developing APD in LCH children with CDI followed in our institution. Methods:
We retrospectively analysed 44 patients over a median period
(quartiles) of 12.3 years (8.79-14.24). Patients were subdivided into
group 1 and group 2, according to absence or presence of APD,
respectively. The main variables studied were: (1) chronological age
(CA) at LCH diagnosis, (2) the primary site of LCH at diagnosis: low
risk (LR) and multisystemic risk organs, and (3) the presence of
reactivation. Results: Multivariate Cox regression
analysis showed that APD was positively associated with CA at LCH
diagnosis [relative risk (RR) 1.14, p < 0.01], the LR clinical form (RR 8.6, p < 0.03), and negatively associated with the presence of reactivations (RR 0.3, p < 0.01). Conclusions:
Patients with older CA at LCH diagnosis, LR clinical forms, and fewer
reactivation episodes might represent a subgroup of paediatric LCH CDI
patients with a higher risk of developing APD.