WP58 - Monoamine GPCRs - Homo sapiens

G protein–coupled receptors (GPCRs) which are also known as seven-(pass)-transmembrane domain receptors, 7TM receptors, heptahelical receptors, serpentine receptor, and G protein–linked receptors (GPLR), constitute a large protein family of receptors that detect molecules outside the cell and activate internal signal transduction pathways and, ultimately, cellular responses. Coupling with G proteins, they are called seven-transmembrane receptors because they pass through the cell membrane seven times. Source: [Wikipedia](https://en.wikipedia.org/wiki/G_protein–coupled_receptor) Monoamine GPCRs are Rhodopsin-like GPCRs that bind to monoamine neurotransmitters. [Monoamine neurotransmitters](https://en.wikipedia.org/wiki/Monoamine_neurotransmitter)