GRADE evidence profile of RCTs for compare CTDR and ACDF in midterm follow-up.

GRADE = Grading of Recommendations Assessment, Development and Evaluation; CTDR = cervical total disc replacement; ACDF = anterior cervical decompression and fusion; NDI = neck disability index; NRS = numerical rating scale.
* inadequate blinding, lack of allocation concealed in some trials may increase risk of bias;
Ϯ inconsistent report of outcomes and significant heterogeneity existed across the trials, but all were well explained by the subgroup analysis;
ᵷ if a study has a wide confidence interval around the estimate of the effect, or included patients less than 400, it may cause imprecision;
GRADE evidence profile of RCTs for compare CTDR and ACDF in midterm follow-up.