Table S1 - Elucidation of the Glucose Transport Pathway in Glucose Transporter 4 via Steered Molecular Dynamics Simulations

Hydrogen bonding and hydrophobic interactions with tunnel lining residues. A detailed list of hydrogen bonding and hydrophobic interactions of sugar molecule with the tunnel residues of the transporter. To calculate the hydrogen bonds, a distance cut off of 3.5 A0 and an angle cut off 300 was used. A distance cut-off of < = 3 A0 between any non hydrogen atom of sugar and ring of residues Trp, Tyr and Phe was used for the calculation of hydrophobic interactions. Position represents the location of the bond forming residue in the transporter. Residues shown as underlined bold are those biochemically demonstrated to play a role in glucose transport (in GLUT1). These interactions were consistent in all SMD trajectories.
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