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Total Syntheses of (+)-α-Allokainic Acid and (−)-2-epi-α-Allokainic Acid Employing Ketopinic Amide as a Chiral Auxiliary

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Figshare2018-08-14 更新2026-04-29 收录
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https://figshare.com/articles/dataset/Total_Syntheses_of_-_-Allokainic_Acid_and_-2-_i_epi_i_-_-Allokainic_Acid_Employing_Ketopinic_Amide_as_a_Chiral_Auxiliary/6965393
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Asymmetric Michael reaction of iminoglycinate 4 to α,β-unsaturated esters had been developed with >98:1 and (−)-2-epi-α-allokainic acid 6 each in 11 synthetic steps starting from 4 in 17.8 and 18.0% yields, respectively.
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2018-08-14
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