HDAC11 Regulates the Proliferation of Bovine Muscle Stem Cells through the Notch Signaling Pathway and Inhibits Muscle Regeneration

Myogenesis is an essential process that can affect the
yield and
quality of beef. Transcriptional studies have shown that histone deacetylase
11 (HDAC11) was differentially expressed in muscle tissues of 6 and
18 month old Longlin cattle, but its role in the regulation of myogenesis
remains unclear. This study aimed to determine the role of HDAC11
in the proliferation and differentiation of bovine muscle stem cells
(MuSCs). HDAC11 promoted MuSC proliferation by activating Notch signaling
and inhibited myoblast differentiation by reducing MyoD1 transcription.
In addition, overexpression of HDAC11 inhibited the repair regeneration
process of muscle in mice. HDAC11 was found to be a novel key target
for the control of myogenesis, and this is a theoretical basis for
the development of HDAC11-specific modulators as a new strategy to
regulate myogenesis.