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Regional identity of human neural stem cells determines oncogenic responses to histone H3.3 mutants. Regional identity of human neural stem cells determines oncogenic responses to histone H3.3 mutants

NIAID Data Ecosystem2026-03-12 收录

神经干细胞区域特异性

组蛋白突变致癌机制

数据链接：

https://www.ncbi.nlm.nih.gov/bioproject/PRJNA685155 数据链接链接失效反馈

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资源简介：

This SuperSeries is composed of the SubSeries listed below. Overall design: Refer to individual Series

应用场景：

创建时间：

2020-12-14

组蛋白突变致癌机制

肉瘤转录组表观遗传

The goal of this study is to understand the alterations in transcriptome induced by histone H3K36M mutations Overall design: Transcritome profiling of C3H101/2 cells cultured in vitro and expressing 8

NIAID Data Ecosystem20

Dual interactions of K27M mutant nucleosomes with PRC2 and MLL1 shape the cancer epigenetic landscape (MARS-seq)

组蛋白突变致癌机制

胶质瘤表观遗传学

Cancer associated mutations in genes encoding histones dramatically reshape chromatin patterns and support tumorigenesis, despite their low prevalence. Lysine to Methionine substitution of residue 27

NIAID Data Ecosystem10

Regional identity of human neural stem cells determines oncogenic responses to histone H3.3 mutants [ChIP-Seq]

儿童肿瘤表观遗传学

组蛋白突变致癌机制

Point mutations within the histone H3.3 are frequent in aggressive childhood brain tumours known as paediatric high-grade gliomas (pHGGs). Intriguingly, different mutations arise in discrete anatomica

NIAID Data Ecosystem10

H3.3K27M cooperates with p53 loss and Pdgfra gain in mouse embryonic neural progenitor cells to induce invasive high-grade gliomas [Human RNA-Seq]. Homo sapiens

儿童高级别胶质瘤转录组

组蛋白突变致癌机制

Gain-of-function mutations in histone 3 (H3) variants are found in a large proportion of pediatric high-grade gliomas (pHGG) and are often associated with p53 loss and PDGFRA amplification. However, a

NIAID Data Ecosystem20

Spontaneous DIPG Modeling Reveals Novel H3.3 K27M-Mediated Oncogenic Mechanisms Acting Through Epigenetic Effects [RNA-seq]

DIPG建模

组蛋白突变致癌机制

A mouse knock-in model engineered for Cre recombinase-activated expression of the endogenous mouse H3f3a allele generating an epitope-tagged H3.3 equipped with or without a K27M mutation to investigat

NIAID Data Ecosystem10

Regional identity of human neural stem cells determines oncogenic responses to histone H3.3 mutants. Regional identity of human neural stem cells determines oncogenic responses to histone H3.3 mutants

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