High-Throughput RNA Sequencing Reveals the Effect of NB- UVB Phototherapy on Major Inflammatory Molecules of Lesional Psoriasis

We report the high-throughput profiling of tissue biopsy from psoriasis skin before the start of NB-UVB therapy and after the last treatment session.RNA sequencing (RNA-Seq) was conducted to assay the transcriptomes and identify differentially expressed transcripts enriched in major pathway analysis. Our results support that clinically effective NB-UVB therapy is based on suppression of a broad range of inflammatory signaling pathways, gene expression of inflammatory cytokines, and increased the expression of anti-inflammatory signaling pathways in psoriatic skin. This study aimed to understand the mechanisms of psoriasis through analyzing differentially expressed genes with RNA-Seq technique by using phototherapy. This research was conducted in patients with moderate to severe plaque-type psoriasis who received NB-UVB treatment.