Crystal structure of human STING in complex with the agonist MD1202D

Crystal structure of human STING in complex with the agonist MD1202D Descriptor: 9-[(1~{S},3~{R},6~{R},8~{R},9~{R},10~{R},12~{R},15~{R},17~{R},18~{R})-8-(6-aminopurin-9-yl)-9,18-bis(fluoranyl)-3,12-bis(oxidanylidene)-3,12-bis(sulfanyl)-2,4,7,11,13-pentaoxa-3$l^{5},12$l^{5}-diphosphatricyclo[13.2.1.0^{6,10}]octadecan-17-yl]-1~{H}-purin-6-one, Stimulator of interferon genes protein Authors: Klima, M, Boura, E. Deposit date: 2023-05-19 Release date: 2023-12-20 Last modified: 2024-04-17 Method: X-RAY DIFFRACTION (3.23 Å) Cite: Fluorinated cGAMP analogs, which act as STING agonists and are not cleavable by poxins: Structural basis of their function. Structure, 32, 2024