Supporting data for “PhageGE: An interactive web platform for exploratory analysis and visualisation of bacteriophage genomes”

Antimicrobial resistance is a serious threat to global health. Due to the stagnant antibiotic discovery pipeline, bacteriophages (phages) have been proposed as an alternative therapy for the treatment of infections caused by multidrug-resistant (MDR) pathogens. Genomic features play an important role in phage pharmacology. However, our knowledge of phage genomics is sparse and the use of existing bioinformatic pipelines and tools requires considerable bioinformatic expertise. These challenges have substantially limited the clinical translation of phage therapy.<br> We have developed PhageGE (Phage Genome Explorer), a user-friendly graphical interface application for the interactive analysis of phage genomes. PhageGE enables users to perform key analyses, including phylogenetic analysis, visualisation of phylogenetic trees, prediction of phage lifecycle, and comparative analysis of phage genome annotations. The new R Shiny webserver, PhageGE, integrates existing R packages and combines them with several newly developed functions to facilitate these analyses. Additionally, the webserver provides interactive visualisation capabilities and allows users to directly export publication-quality images.<br> PhageGE is a valuable tool that simplifies the analysis of phage genome data and may expedite the development and clinical translation of phage therapy. PhageGE is publicly available at http://phagege.com